Our research addresses two fundamental questions:
(i) how does the G-protein coupled receptor (GPCR) signaling system work? and
(ii) can we use this knowledge to design new ligands that control specific pathways and biological functions?
To answer those questions, we focus on structure-function,
dynamics, and pharmacology of the GPCR superfamily, probing it with state-of-the-art
structural bioinformatics and molecular modeling tools,
and validating the predictions with experimental data from public sources and collaborators.
